Botox vs. Collagen Boosters: Which is best for the treatment of Wrinkles?

Posted by admin on September 30, 2022

One of the most common questions Dr Edwin receives for the treatment of wrinkles is – what is the best skincare ingredient to stimulate collagen to improve wrinkles? 

What are the differences between Botox vs Collagen Boosting treatments like Rejuran Healer or Profhilo? 

Which treatment is superior? 

Can they be done together? 

And finally, what one is right for you? This article will answer these questions and more.

What is the Difference Between Botox and Collagen Boosting Treatments?

Collagen is an essential component of the skin. It contributes to the skin’s elasticity, thickness, and texture. Simply put, the higher the levels of collagen in the skin, the younger the skin looks and the quicker the skin can bounce back after facial movement.

An example is a fresh rubber band. When you stretch and release it the first few times, it will return to its original shape. However, the more it is stretched, the looser the rubber band becomes and after a while, it is no longer able to retain its shape.

Hence, in babies and young children who have high levels of collagen in their skin, you will not see them having wrinkles even though they may scrunch up their faces when crying. However, it is common to observe facial wrinkles in those in their 50s and older because of the lower levels of collagen in their skin due to the aging process. Furthermore, repetitive facial movements accumulated over the years will worsen the appearance of wrinkles. 

As such, collagen boosting treatments serve to increase the amount of collagen in the skin to increase elasticity and improve the signs of aging such as wrinkles, fine lines, skin thinning and skin laxity.

Although Botox does not stimulate collagen production, Botox helps to improve wrinkles by blocking the transmission of nerve signals in the muscles. The decrease in muscle activity results in the improvement of wrinkles and fine lines in the face.

How does the Rejuran Healer Collagen Boosting Treatment work?

Rejuran Healer is made of Polynucleotides which are derived from salmon DNA. Polynucleotides are DNA fragments that help to repair damaged skin cells and stimulate collagen production by increasing the proliferation of fibroblasts. 

Studies have shown that Polynucleotides extracted from salmon DNA are very safe and compatible with human skin.

It is injected in a series of precise micro injections into the skin, covering the entire face. It can also be targeted at specific areas such as the undereye area for example. 

Rejuran healer treatments are recommended to be done once a month for three consecutive months for best results.

Learn more about Rejuran healer here

Profhilo – Another Collagen Boosting Treatment

For patients who wish to stimulate collagen production and increase the skin’s hydration concurrently, Profhilo injections are highly recommended for such an indication. This is especially useful for people who have both wrinkles and fine lines because of dry aging skin.

Known as 逆時針 or “Time Reversing Injection”, Profhilo is the latest multi-purpose injectable treatment for skin rejuvenation, hydration and collagen stimulation.

Profhilo’s selling point is that it has one of the highest concentrations of Hyaluronic acid (HA) on the market - 64 mg in 2 mls. 

Each treatment only requires 5 injection points in each cheek, 10 points in total. Compared to Rejuran Healer which may have more than 30 injections, Profhilo is very well received by those who are not keen on too many injections.

Learn more about Profhilo at

Should Botox or Collagen Boosting Treatments be done first?

Patients who desire quick results will find that Botox delivers faster wrinkle improvement for areas such as the forehead, frown lines, and crow's feet area.

Hence, for those on a short timeline, for example - brides getting married in 2 weeks would benefit more from Botox treatments to address those wrinkles mentioned above.

However, for wrinkles in areas such as the cheeks or jowls where botox is not recommended due to the risk of weakening important muscles of facial expression, collagen boosting treatments such as Rejuran Healer and Profhilo will be the treatment of choice. 


So which one is better? Botox or collagen boosting injections? In my opinion, both are crucial when it comes to anti-aging benefits and both treatments should be done together for the best anti-wrinkles results. 

In summary, increasing collagen levels in the skin whilst reducing facial muscle movement with Botox will be the most effective way in improving the appearance of wrinkles and fine lines. 

Before making a decision about whether to undergo Botox or collagen-boosting treatments, it's important to consult with a doctor who can help you determine if either option would be best for you.

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