Daily oral semaglutide tablet therapy is a doctor-supervised option for weight loss available in Singapore. As the only GLP-1 receptor agonist in tablet form, this medication delivers the same active ingredient found in weekly injection pens, but in a once-daily oral dose.
Produced by a leading Danish pharmaceutical company Novo Nordisk, this oral GLP-1 tablet is widely recognised internationally as the tablet form of semaglutide. It offers a discreet and injection-free approach for individuals who prefer a non-injectable solution for medical weight management.
Oral semaglutide works by mimicking natural hormones that regulate appetite and increase feelings of fullness. This helps reduce hunger and supports gradual, sustainable weight loss under doctor supervision.
This page explains how daily oral semaglutide tablets can be used as part of a weight management plan in Singapore. You will find information on how this therapy works, the expected benefits and results, dosing schedule, safety considerations, and what to expect during your treatment journey.
Daily oral semaglutide tablets are prescribed in Singapore for individuals seeking doctor-led, prescription weight loss support without the need for injections. As the only oral GLP-1 tablet approved for weight management in Singapore, this therapy provides a convenient alternative to injectable weight loss medications.
Understanding how this oral GLP-1 therapy works can help you make informed decisions about your treatment options and set realistic expectations for your weight loss journey.
Oral semaglutide belongs to a class of medications called GLP-1 receptor agonists. These tablets mimic natural hormones released after eating to help:
By supporting appetite control and reducing daily caloric consumption, oral GLP-1 tablet therapy can help patients in Singapore achieve gradual, sustainable weight loss—especially when combined with medical supervision, healthy diet, and regular physical activity.
When used as part of a structured, doctor-supervised weight loss programme, daily oral semaglutide tablets have been shown to help patients achieve significant and clinically meaningful reductions in body weight.
This non-injectable prescription weight loss tablet is especially suitable for adults who are overweight or obese and have not achieved sufficient results with lifestyle modification alone.
Additional benefits may include:
For a comparison of oral and injectable GLP-1 therapies for weight loss, see our injectable semaglutide guide.
Proper use of daily oral semaglutide tablets is essential for safe and effective weight loss. This section explains who is suitable for this therapy, the recommended dosing and titration schedule, and key administration instructions for patients in Singapore.
Oral semaglutide tablets are prescribed to adults who are overweight (BMI ≥27 kg/m² with a weight-related medical problem) or obese (BMI ≥30 kg/m²), especially when diet and exercise alone have not resulted in adequate weight reduction.
Suitability is determined after a thorough consultation with Dr Edwin or our clinic team, who will review your medical history, current medications, and weight loss goals to ensure this oral GLP-1 therapy is safe and appropriate.
The typical dosing schedule for daily oral semaglutide tablets begins with a low starting dose of 3 mg once daily for the first 30 days.
After this initial period, the dose is usually increased to 7 mg once daily, and if further weight loss is desired and the medication is well tolerated, the dose may be further increased to a maximum of 14 mg once daily.
Dose adjustments are made gradually to minimize gastrointestinal side effects, and your progress will be closely monitored at each clinic review.
For best results and absorption, oral semaglutide tablets should be taken once daily on an empty stomach, with a small amount of plain water (up to 120 mL). It is important to wait at least 30 minutes after taking the tablet before eating, drinking, or taking any other oral medications.
Consistency in timing and proper administration helps maximise the medication’s effectiveness and supports your weight loss goals.
Our clinic provides clear guidance and support on how to use daily oral GLP-1 tablets, manage your dosing schedule, and address any questions or concerns throughout your treatment journey.
Daily oral semaglutide tablets, prescribed in Singapore for weight loss, have been rigorously evaluated in both clinical trials and real-world studies. Understanding this evidence will help you set clear expectations for your treatment.
Oral semaglutide’s effectiveness for weight management has been demonstrated in international clinical trials. In these studies, participants taking daily oral semaglutide achieved greater weight loss compared to those receiving placebo or other active medications, especially when the medication was used alongside healthy lifestyle changes and clinic supervision.
On average, patients on oral semaglutide experienced a reduction of 4 to 5 kilograms in body weight over six months. Longer-term real-world data suggests that individuals may achieve even more substantial weight loss, with some patients losing over 10% of their starting weight after one year of consistent use under medical supervision.
For further reading, see the PIONEER 4 clinical trial:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31271-1/abstract
These findings support the use of oral GLP-1 tablets as an effective option for patients seeking a non-injectable weight loss therapy.
At our Singapore clinic, patients using daily oral semaglutide tablets as part of a structured, doctor-supervised weight loss programme typically achieve 4–8% reduction in body weight over several months.
Some patients experience greater weight loss, especially when they are fully engaged with clinic follow-up, dietary guidance, and exercise plans. Dr Edwin and our team provide ongoing monitoring and support to ensure that weight loss is both safe and sustainable with oral GLP-1 therapy.
Starting daily oral semaglutide therapy at our clinic involves a step-by-step, doctor-supervised approach to ensure safety, comfort, and the best possible results.
Knowing what to expect at each stage of your treatment can help you feel more confident and prepared for your weight loss journey.
Your journey with oral GLP-1 weight loss tablets begins with a comprehensive consultation at our clinic. Dr Edwin or our doctors will assess your medical history, current medications, previous weight management attempts, and lifestyle factors.
Laboratory tests may be recommended to check your blood sugar, kidney and liver function, and other health indicators. This careful evaluation ensures that oral semaglutide therapy is safe and appropriate for your individual needs.
If you are suitable for oral semaglutide therapy, our clinic team will provide detailed instructions on how to take your daily tablet for the best results.
You will learn about the importance of the timing of each dose, when to consume food and other medications, and how to incorporate the tablet into your daily routine.
Written instructions and demonstration videos are available to help you get started. Our staff are always available to answer any questions or provide support with administration.
After starting therapy, you will have regular follow-up appointments at our clinic. These visits allow our team to monitor your weight loss progress, review laboratory results, adjust your dosage if necessary, and help you manage any side effects.
Dr Edwin and our clinic staff provide personalised advice on nutrition, exercise, and lifestyle changes to support your weight loss goals. Ongoing support ensures you stay motivated, overcome challenges, and achieve lasting results with oral GLP-1 therapy.
Daily oral semaglutide tablets are generally well tolerated when prescribed under medical supervision, but as with all medications, patients should be aware of possible side effects and safety considerations.
Understanding these factors can help you use oral GLP-1 therapy safely and know when to seek further advice.
The most common side effects of oral semaglutide weight loss tablets are related to the digestive system.
These include nausea, vomiting, diarrhoea, constipation, and mild abdominal discomfort. Side effects are most likely to occur during dose escalation and typically become milder or resolve over time as your body adjusts to the medication.
Drinking water regularly, eating smaller meals, and avoiding high-fat foods can help reduce discomfort. Our clinic will provide guidance on managing these symptoms if they occur.
Although uncommon, some patients may experience more serious side effects with oral semaglutide therapy. These include severe or persistent vomiting, dehydration, severe abdominal pain (which may indicate pancreatitis), and signs of an allergic reaction such as swelling, rash, or difficulty breathing.
If you experience any severe or ongoing symptoms, you should contact Dr Edwin or our clinic immediately, or seek urgent medical care.
Oral semaglutide tablets are not suitable for everyone. Individuals with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, active pancreatitis, or severe kidney or liver disease should not use this medication.
Women who are pregnant, planning to become pregnant, or breastfeeding are also advised against oral GLP-1 therapy. During your initial consultation, Dr Edwin or our clinic team will review your full medical history to ensure that oral semaglutide is safe and appropriate for your needs.
For individuals exploring doctor-supervised weight loss medication in Singapore, both oral semaglutide tablets and injectable GLP-1 receptor agonists are available.
Understanding the main differences between these therapies can help you and your doctor determine which approach best suits your preferences, lifestyle, and weight management goals.
Oral semaglutide is taken as a once-daily tablet, offering a needle-free alternative for medical weight management. Injectable GLP-1 therapies are available in both daily and once-weekly formulations and are administered as a subcutaneous injection using a pre-filled pen device.
The once-weekly injectable, produced by the same leading Danish pharmaceutical company, is widely used internationally for weight loss and is known for its higher-dose protocol. The daily injectable (liraglutide), also a GLP-1 receptor agonist, has been a common option for those requiring a more frequent dosing routine.
Many patients appreciate the simplicity of a daily oral tablet, particularly if they prefer to avoid injections or travel frequently. On the other hand, injectable options may appeal to those who prefer not to take a tablet every day or who are comfortable with a weekly injection schedule.
Both oral and injectable GLP-1 receptor agonist therapies have been shown to support meaningful, clinically significant weight loss under doctor supervision.
International research and experience in Singapore suggest that higher-dose, once-weekly injectable GLP-1 therapies may achieve slightly greater average weight loss compared to daily oral semaglutide tablets.
However, the oral tablet remains an effective, evidence-based solution for patients seeking a non-injectable approach, especially when combined with medical supervision, nutrition, and lifestyle changes.
Choosing between oral and injectable GLP-1 therapies depends on your medical background, treatment goals, and personal preferences.
Oral semaglutide tablets are ideal for adults seeking a convenient, needle-free weight loss solution, or for those who do not tolerate injections well.
Injectable therapies, including both daily and once-weekly dosing options, may be recommended for patients needing more intensive weight management or tailored dosing regimens.
During your consultation, our clinic team will review your health profile, answer questions about both oral and injectable GLP-1 therapies, and recommend the most suitable strategy to help you achieve and sustain your weight loss goals.
Apart from daily oral GLP-1 tablet therapy, Singapore doctors may prescribe other oral weight loss medications with distinct mechanisms of action. These alternatives are usually considered for individuals who cannot use GLP-1 therapies or need additional support for weight reduction.
One widely used oral weight loss medication is a fat absorption blocker containing orlistat. This medication works by inhibiting the enzymes that digest fat in the gastrointestinal tract, resulting in a portion of dietary fat being excreted rather than absorbed.
Orlistat is typically taken with main meals. Patients using this therapy may experience gastrointestinal side effects such as oily stools or more frequent bowel movements, especially if their diet is high in fat. For best results, adherence to a low-fat diet is recommended.
Another group of oral weight loss medications includes centrally acting appetite suppressants such as phentermine. These medications work by stimulating specific centres in the brain that help decrease hunger and reduce calorie intake.
Phentermine and similar compounds are typically prescribed for short-term use and may be suitable for individuals who require weight reduction under close doctor supervision. Potential side effects include dry mouth, insomnia, increased heart rate, and mood changes, so regular monitoring is required.
Some oral weight loss pills combine different active ingredients to target multiple pathways. For example, naltrexone-bupropion is a combination therapy that acts on both appetite regulation and the brain’s reward system to help control food cravings and reduce overeating.
Combination therapies are usually reserved for patients who have not achieved sufficient results with single-agent medications and require a more tailored approach.
The most suitable oral weight loss medication depends on your medical history, treatment goals, and any underlying health conditions.
At our clinic, Dr Edwin or our team will carefully evaluate all available options, discuss expected benefits and side effects, and recommend the therapy most likely to help you achieve safe and effective weight loss.
To learn more about your options for oral weight loss medications, schedule a consultation with our clinic for a personalised assessment and evidence-based treatment plan.
When considering medical weight loss therapy in Singapore, it’s important to understand how daily oral GLP-1 tablets compare to other doctor-prescribed options, including various injectable and oral medications. The table below highlights the main differences in active ingredients, dosing schedules, effectiveness, and key considerations. This overview can help you and your doctor choose the most appropriate treatment plan for your weight loss needs and lifestyle.
| Therapy Type | Active Ingredient | Administration | Typical Dosing | Average Weight Loss | Key Considerations | Best Suited For |
| Daily Oral GLP-1 Tablet | Semaglutide | Oral tablet | 3–14 mg once daily | 4–8% body weight | Only GLP-1 in oral form, convenient, no injection | Adults preferring needle-free therapy |
| Once-Weekly Injectable GLP-1 | Semaglutide (high dose) | Subcutaneous injection | 0.25–2.4 mg weekly | Up to 15% body weight | Weekly dosing, high efficacy, doctor guidance needed | Those needing greater efficacy |
| Daily Injectable GLP-1 | Liraglutide | Subcutaneous injection | Up to 3 mg daily | 6–12% body weight | Daily injection, steady effect, meal timing important | Adults preferring daily routine |
| Weekly Dual Receptor Injectable | Tirzepatide | Subcutaneous injection | 2.5–15 mg weekly | Up to 20% body weight | Acts on two pathways, higher average results | Higher BMI, metabolic syndrome |
| Oral Non-GLP-1 Weight Loss Pill | Orlistat, Phentermine, etc. | Oral capsule/tablet | Varies | 3–7% body weight | Not a GLP-1, different mechanism, may affect GI or CNS | Patients unable to use GLP-1 therapies |
Daily oral semaglutide therapy is most effective when combined with a healthy diet, regular physical activity, and sustainable lifestyle habits. This integrated approach supports more significant and lasting weight loss for patients in Singapore.
Adopting a balanced, nutrient-rich diet helps to maximise the appetite-reducing benefits of oral GLP-1 weight loss tablets. Patients are encouraged to focus on whole foods such as lean proteins, vegetables, fruits, and whole grains while limiting processed, high-sugar, and high-fat foods. Mindful eating practices and appropriate portion control can further support weight management.
Physical activity is another key factor in achieving and maintaining weight loss. Regular exercise—such as walking, cycling, or strength training—not only increases energy expenditure but also helps preserve muscle mass and support overall metabolic health. Our clinic provides tailored advice on incorporating safe, effective exercise into your routine, regardless of your starting fitness level.
Long-term weight loss is best achieved with sustainable changes in behaviour. Setting realistic goals, tracking your progress, and identifying triggers for overeating can help maintain motivation. Our clinic team offers ongoing support and structured follow-up to reinforce healthy habits and address challenges as they arise.
Dr Edwin and our clinical team are committed to providing patients with comprehensive education, meal planning guidance, exercise recommendations, and encouragement at every stage. Combining daily oral semaglutide tablets with evidence-based lifestyle strategies offers the greatest chance of safe, successful, and lasting weight loss.
What Is Oral Semaglutide and How Does It Help With Weight Loss?
Oral semaglutide tablets, such as Rybelsus, work by mimicking hormones that regulate appetite and fullness. Rybelsus helps reduce hunger, leading to gradual and sustainable weight loss when combined with medical supervision and healthy lifestyle changes.
Who Is Suitable for Oral GLP-1 Weight Loss Tablets in Singapore?
Rybelsus is prescribed to adults with overweight or obesity who have not achieved adequate results through diet and exercise alone. Suitability is assessed by your doctor based on your BMI, medical history, and weight-related health conditions.
How Should Oral Semaglutide Tablets Be Taken for Best Results?
Rybelsus is taken once daily, on an empty stomach with a small amount of water. You should wait at least 30 minutes before eating, drinking, or taking other medications to ensure optimal absorption and effectiveness.
How Long Does It Take to See Weight Loss Results With Oral GLP-1 Therapy?
Many patients notice a decrease in appetite and some initial weight loss within a few weeks of starting Rybelsus. More significant results typically develop after several months of ongoing use, especially with consistent medical supervision and lifestyle support.
What Are the Common Side Effects of Oral Semaglutide Tablets?
The most common side effects of Rybelsus include nausea, vomiting, diarrhoea, constipation, and mild abdominal discomfort, especially during dose escalation. These symptoms are usually temporary. More serious side effects are rare, but your doctor will monitor you closely during treatment.
Can Oral GLP-1 Tablets Be Used With Other Weight Loss Medications?
It is not recommended to combine Rybelsus with other GLP-1 medications, such as injectable semaglutide (commonly used in weekly injection pens), daily injectable liraglutide, or dual receptor therapies like those found in certain once-weekly injectables. Always consult your doctor before combining therapies.
Can I Switch From Injectable GLP-1 Therapy to Oral Semaglutide Tablets?
Yes, many patients switch from injectable GLP-1 medications to Rybelsus for convenience or preference. This transition should be managed by your doctor to ensure safe dose adjustment and ongoing effectiveness.
Is Oral Semaglutide Safe During Pregnancy or Breastfeeding?
Rybelsus is not recommended for women who are pregnant, planning to become pregnant, or breastfeeding. Always discuss alternative weight management options with your doctor if you are considering pregnancy.
What Is the Typical Cost of Oral GLP-1 Weight Loss Tablets in Singapore?
The cost of Rybelsus typically ranges from $300 to $400 per month, depending on dosage and clinic pricing. This may differ from the cost of injectable GLP-1 therapies. For up-to-date pricing, please contact our clinic.
How Long Should Oral Semaglutide Therapy Be Continued?
The duration of Rybelsus treatment varies for each individual, but many patients continue therapy for 6 to 12 months or longer under doctor supervision to maintain weight loss and metabolic health.
What Should I Do If I Miss a Dose of Oral GLP-1 Weight Loss Tablets?
If you miss your daily dose of Rybelsus, take it as soon as you remember if it’s within 12 hours. If more than 12 hours have passed, skip the missed dose and resume your usual schedule. Do not double the dose.
Can Oral Semaglutide Therapy Improve Metabolic Health?
Along with weight loss, Rybelsus may help improve blood sugar control and reduce risk factors linked to metabolic syndrome, depending on your health profile. Your doctor will tailor treatment to your specific goals.
Are There Food or Medication Interactions With Oral GLP-1 Tablets?
Rybelsus should be taken on an empty stomach, and you should wait 30 minutes before consuming food, drink, or other medications. Your doctor will guide you on managing other prescriptions during your oral semaglutide therapy.
What Lifestyle Changes Support the Best Results With Oral GLP-1 Weight Loss Tablets?
Combining Rybelsus with a balanced diet, regular exercise, and healthy habits will maximize your weight loss and support lasting results. Our clinic provides individualized support for lifestyle change alongside medical treatment.
How Is Oral Semaglutide Different From Injectable GLP-1 Weight Loss Medications?
Oral semaglutide (Rybelsus) is taken as a once-daily tablet, while injectable GLP-1 therapies such as Ozempic, Wegovy or Mounjaro are given as subcutaneous injections, either daily or weekly. Although both contain GLP-1 receptor agonists for weight loss, the oral tablet offers a needle-free, convenient option for those who prefer not to inject.
Is Oral GLP-1 Weight Loss Therapy as Effective as Injectable Versions?
Rybelsus can produce significant weight loss under medical supervision, but clinical studies show that weekly injectable GLP-1 therapies (like Ozempic, Wegovy or Mounjaro) may result in slightly greater average weight loss. Your doctor can help you decide which option is best for your goals.
Are There Any Medical Conditions That Prevent Use of Oral GLP-1 Tablets?
Oral semaglutide is not suitable for patients with a history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, pancreatitis, or severe kidney or liver disease. Your suitability for Rybelsus will be determined during a comprehensive consultation.
Can Oral Semaglutide Be Used for Weight Loss Without Diabetes?
Yes, Rybelsus is prescribed for weight loss in adults with overweight or obesity, even if they do not have diabetes. Medical supervision is required to ensure safety and proper use.
Can I Use Oral GLP-1 Tablets for Long-Term Weight Maintenance?
Many patients continue Rybelsus for extended periods to help maintain weight loss and metabolic benefits, as long as the therapy is well-tolerated and monitored by a doctor.
Is Blood Test Monitoring Needed While on Oral Semaglutide Weight Loss Tablets?
Yes, regular blood tests to monitor metabolic health, kidney function, and other health markers are recommended during therapy with Rybelsus. Your clinic will advise on the best schedule for follow-up assessments.
What Should I Do if I Experience Side Effects With Oral GLP-1 Therapy?
If you experience side effects while using Rybelsus, notify your doctor promptly. Adjustments in dose, dietary changes, or temporary pauses may be recommended to improve comfort and safety.
How Do I Start Oral Semaglutide Weight Loss Therapy in Singapore?
To begin Rybelsus therapy, schedule a consultation with our clinic. Dr Edwin or our team will assess your eligibility, explain the process, and develop a personalised weight loss plan tailored to your needs.
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